Bruton tyrosine kinase inhibitors (BTKi) have transformed the treatment of B-cell malignancies, but intolerance has often led to their discontinuation.The phase 1/2 BRUIN study evaluated pirtobrutinib, a highly selective non-covalent (reversible) BTKi, in patients with R/R B-cell malignancies Throat Support (NCT03740529).Pirtobrutinib was investiga
Extradural hematoma (EDH) is a rare but serious Isolator complication of brain injury.The supra- and infra-tentorial EDH is even rarer and only a few articles focusing on this topic have been published.The clinical manifestations are nonspecific but early diagnosis of supra- and infra-tentorial EDH and prompt treatment are mandatory to avoid compli
This paper compares the compliance level of Australian StockExchange (ASX) listed construction and non-constructioncompanies with the ASX Corporate Governance Council (CGC)recommendations on sound corporate governance.It alsoexamines the difference in board characteristics between thetwo groups, paying particular attention to differences in boardin
Environmental management of coastal aquaculture is focused on acute impacts of organic and nitrogenous wastes close to farms.However, the energy-rich trophic subsidy that aquaculture provides may create cascades with influences over broader spatial scales.In a fjord region with intensive fish farming, we tested whether an ecosystem engineer, the wh
Mantle cell lymphoma (MCL) is a malignant B-cell Concealers neoplasm, which comprises monomorphic and small- to medium-sized mantle zone-derived lymphoid cells.It is characterized by chromosomal translocation t(11;14)(q13;q32) and CCND1 truncation, resulting in cell cycle deregulation.It is an aggressive type of non-Hodgkin lymphoma with a propensi